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文献回顾组织工程细胞片可有效递送脂肪 [复制链接]

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EngineeredCellSheetsfortheEffectiveDeliveryofAdipose-DerivedStemCellsforTendon-to-BoneHealing

组织工程细胞片可有效递送脂肪干细胞以进行肌腱-骨的愈合

作者:MyungJinShin,InKyongShim,DongMinKim,JaeHeeChoi,YuNaLee,In-HoJeon,HyojuneKim,DongjunPark,EricaKholinne,Ha-SolYang,KyoungHwanKoh

杂志:AmJSportsMed.

DOI:10./

IF:5.81

Background

Effortsarebeingmadetotreatrotatorcufftears(RCTs)thatexhibitpoorhealingandhighretearrates.Tendon-to-bonehealingusingmesenchymalstemcellsisbeingexplored,butresearchisneededtoestablisheffectivedeliveryoptions.

人们正在努力治疗不良愈合和高复发的肩袖撕裂症(RCT)。人们正在探索使用间充质干细胞进行肌腱-骨的愈合,但是需要研究有效的递送选择。

Purpose

Toevaluatetheeffectsofanadipose-derivedstemcell(ADSC)sheetonmesenchymalstemcelldeliveryfortendon-to-bonehealingofachronicRCTinratsandtodemonstratethatADSCsheetsenhancetendon-to-bonehealing.

评估脂肪来源干细胞(ADSC)片对间充质干细胞递送的大鼠慢性RCT的肌腱-骨愈合的影响,并证明ADSC片增强肌腱-骨的愈合。

Studydesign

Controlledlaboratorystudy.

对照实验室研究

Methods

Mesenchymalstemcellswereobtainedfromratadiposetissue,andacellsheetwaspreparedusingatemperature-responsivedish.Toevaluatetheefficacyofstemcellsproducedinasheetforthelesion,theexperimentwasconductedwith3groups:repairgroup,cellsheettransplantationafterrepairgroup,andcellsheet-onlygroup.Histological,biomechanical,andmicro-

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